The Use of Sulfaguanidine for Prophylaxis in Sonne Bacillary Dysentery, and in the Control of the Carrier State *

In an earlier paper the therapeutic effectiveness of sulfathiazole used during the acute stages of Sonne bacillary dysentery was demonstrated.5 However, it was shown also that sulfonamide therapy did not curtail the period during which the Sonne organism could be recovered by rectal cultures. Actually, there appeared to be statistical evidence that this period was prolonged when compared with untreated controls. Another outbreak of Sonne bacillary dysentery occurring two years later afforded us the opportunity to test the value of sulfaguanidine, administered for varying periods during convalescence, for reducing the length of the carrier state. At the same time, the prophylactic value of the sulfonamide drugs in preventing the epidemic spread of bacillary dysentery, as recently suggested,2' 4 was also investigated.